• Vasculitis; It is a clinicopathological process that develops as a result of inflammation in the vessel wall and progresses with local and/or systemic organ attitudes.
• In veins; It causes clinical findings in the target organ by causing many different pictures such as thrombosis, stenosis, aneurysm formation, rupture, bleeding.
• Vasculitides may be primary (idiopathic) or they may occur due to various conditions (secondary)
Great Vessel Vasculitis
Temporal arteritis (Giant cell arteritis)
Medium Vessel Vasculitis
Kawasaki disease
Small Vessel Vasculitis
Eosinophilic granulomatous polyangiitis
Immune complex small vessel vasculitis
Antiglomerular basement membrane disease
Immunoglobulin A vasculitis (Henoch Schonlein)
Hypocomplementemic urticarial vasculitis
Variable vessel vasculitis
Cogan syndrome
Secondary Vasculitis
Associated with systemic disease
lupus vasculitis
Rheumatoid vasculitis
Sarcoid vasculitis
Aortitis associated with IgG4
Associated with a possible pathogenic mechanism
Vasculitis associated with infection such as: syphilis, HBV, HCV.
Vasculitis associated with treatment: allopurinol, sulfonamide
Drug-induced ANCA-associated vasculitis (PTU, Hydralazine)
Clinical findings by vessel diameter
Large Diameter Blood Vessel
Limping in the extremities
The difference in blood pressure and pulse between the extremities
Inability to have a pulse
Aortic dilatation
Hum in the great arteries
Medium Diameter Blood Vessel
Skin nodules / ulcers
reticulum blue
gangrene
polyneuritis mononeuritis
mesenteric ischemia
micro aneurysms
Small Diameter Blood Vessel
Palpable purpura
Glomerulonephritis
Alveolar bleeding
Splinter hemorrhage
Uveitis
Episcleritis, scleritis
Pathophysiology
Mechanism of vascular injury in vasculitis
Immune complex formation
• Immunoglobulin A vasculitis
• Lupus vasculitis
• HCV-associated cryoglobinemic vasculitis
• HBV-associated vasculitis
ANCA formation
• Microscopic polyangiitis
• Granulomatous polyangiitis
• Eosinophilic
• granulomatous polyangiitis