• Differences from PAN
It can cause glomerulonephritis.
o It can cause pulmonary capillaritis (alveolar hemorrhage).
it is ANCA ( + ).
Clinical Findings
• MPA is similar to granulomatous polyangiitis (GPA) in terms of lung involvement (pulmonary capillaritis) and kidney involvement (crescentic glomerulonephritis). However, unlike GPA;
o It is not expected to involve the upper respiratory tract.
o Nodular - cavitary lesions are not seen in the lung.
o There is no granuloma in the biopsy taken from the lesion.
o The majority of patients are pANCA positive.
Treatment
• It is basically like the treatment of granulomatous polyangiitis.