• It is a clinical condition that develops due to Clostrodium difficile after antibiotic use and progresses with a severe colitis picture.
• The most responsible antibiotics are ampiciun, clindamycin and 3rd generation cephalosporins.
It can occur immediately after taking antibiotics or later, such as 8 weeks.
• Patients have malodorous, watery diarrhea and cramp-like abdominal pain. Some patients may experience bloody diarrhea. High fever and leukocytosis may be seen. Colon and rectum involvement is common.
• Diagnosis is made by demonstrating the toxin in the stool. Colonoscopic visualization of colitis and pseudomembranes is helpful in diagnosis.
• Oral metronidazole is the first choice for mild cases. Oral vancomycin is preferred in patients who cannot be given metronidazole or in severe cases. Fidaxomicin and fecal transplantation can also be applied in the treatment.