The Detergents And Disinfectants For Instruments And Surfaces (Hexanios - Surfanios)

Table Of Contents

• cryoglobulins; They are immunoglobulins that precipitate in a cold environment and become soluble in a warm environment.

• Cryoglobulinemic vasculitis

o It is an immunocomplex vasculitis involving small vessels.

o The most common cause is HCV infection.

o Triad: Palpable purpura + arthritis + glomerulonephritis (most common MPGN type 1).

o Elevated liver enzymes and neuropathy (mononeuritis multiplex) may be seen.

o Most of the patients have RF positivity and hypocomplementemia.

o C4 level is lower than C3 level.

o Anti-HCV treatment is given primarily in HCV-associated cryoglobinemic vasculitis.

o Rituximab is used in relapsed or severe cases where antiviral drugs cannot be used.