• It is examined in 2 groups according to epidemiological, clinical, laboratory and histological features.
Type 1 autoimmune pancreatitis is more common.
• Type I autoimmune pancreatitis
The male/female ratio is 2/1.
The average age of application is 60-70.
The most common form of presentation is painless jaundice, acute pancreatitis is less common.
Pancreas is diffusely or focally enlarged
Obstructive jaundice or a mass in the head of the pancreas (mimicking pancreatic cancer) may be seen.
The pancreatic duct is diffusely and irregularly narrowed.
Pancreatic calcification is rare.
Pancreatic biopsy reveals lymphoplasmocytic infiltration (IgG4) and storiform (gradual) fibrosis.
Serum gammaglobulins, especially IgG4, are increased.
May be associated with other autoimmune diseases (Sjögren's syndrome, primary sclerosing cholangitis, ulcerative colitis, rheumatoid arthritis, etc.)
ANA, RF, etc. other autoantibodies may also be seen.
Involvement in other organ systems (biliary strictures, sialoadenitis, pseudotumors in organs and retroperitoneal fibrosis) is common.
Glucocorticoids improve symptoms, reduce pancreatic size, and provide histopathological improvement. Relapses are common after steroid therapy is discontinued.
HISORt diagnostic criteria: Histology, Imaging, Serology, Other organ involvement, Improvement of pancreatic and extrapancreatic findings with steroid therapy
• Type 2 autoimmune pancreatitis
It is seen with equal frequency in men and women and more common in young-middle age.
It is not associated with IgG4.
Other organ involvement is not expected.
Recurrence is rare.