• Humoral immunodeficiencies (50%, It is the most common immunodeficiency)
• Cellular immunodeficiencies (30%)
• Combined immunodeficiency syndromes
• Phagocytic system defects (18%)
• Complement system deficiencies (2%)
• Secondary immunodeficiencies
• The most common clinical manifestation of immunodeficiency in children is recurrent sinopulmonary infections.
Findings suggestive of immunodeficiency in children
• One or more systemic or serious bacterial infections (eg sepsis, osteomyelitis or meningitis)
• Two or more respiratory or documented bacterial soft tissue infections (eg cellulitis, draining otitis media or lymphadenitis) in one year
• Infections in unusual sites (eg liver, brain abscess)
• Infections with uncommon pathogens (Aspergillus, Serratia marcescens, Nocardia or Burkholderia cepacia)
• Infections with common agents but of unusual severity
Moreover
• Growth retardation ± chronic diarrhea
• Persistent infections after live vaccination
• Immunodeficiency should also be suspected in the case of chronic oral or cutaneous moniliasis
